Role Snapshot
The Research Scientist will support the Metabolomics and Proteomics Core at UNC-Chapel Hill and help build an affinity selection mass spectrometry platform to find small-molecule ligands for hard-to-drug proteins within the open-science Structural Genomics Consortium. The role advances freely available reagents and probes for the global research community.
Key Responsibilities: Prepare and process samples for small-molecule analysis, operate and troubleshoot LC-MS platforms and automated liquid handlers, and analyze targeted and untargeted data. The role also involves maintaining research records, training team members, and supporting collaborators with experimental design, with occasional domestic and international travel.
Skills & Tools: Requires expertise in mass spectrometry, liquid chromatography, analytical method development, and drug discovery, along with data analysis and interpretation. Strong independence, troubleshooting ability, and clear communication for training and collaboration are also expected.
Qualifications: Typically requires an advanced degree in a relevant scientific field and hands-on experience with LC-MS instrumentation and small-molecule analysis. Specific years of experience were not stated in the posting.
Compensation: $120K–$180K/yr (estimated)
Job Description
The Structural Genomics Consortium at UNC-Chapel Hill (SGC-UNC) is an open-science research center that generates high-quality reagents, structures, and chemical probes for understudied human proteins and makes them freely available to the global research community without restriction on use. SGC-UNC is establishing a new affinity selection mass spectrometry (ASMS) screening platform to identify small-molecule ligands for proteins that have been intractable to conventional screening approaches.
The Research Scientist will join the Metabolomics and Proteomics (MAP) Core at the University of North Carolina at Chapel Hill, a collaborative shared research facility that supports investigators across UNC and external partners through advanced mass spectrometry, and data analysis services. This position offers an exciting opportunity to contribute to cutting-edge translational and biomedical research while working with multidisciplinary teams on a wide range of sponsored research projects.
The Research Scientist will provide scientific expertise in drug discovery, mass spectrometry, and analytical method development. Responsibilities include preparing and processing samples for small-molecule analyses; operating, maintaining, and troubleshooting advanced instrumentation, including automated liquid handlers, liquid chromatography (LC) and mass spectrometry (MS) platforms; analyzing and interpreting targeted and untargeted experimental data; maintenance and communication of research records and project achievements.
Working with a high degree of independence, the Research Scientist will serve as a key scientific resource supporting team members and collaborators to design experiments, troubleshoot technical challenges, interpret results, and support successful project completion. The position may also provide technical training and guidance on laboratory procedures, instrumentation operation, and best practices to team members and research personnel, advancing the research mission of SGC-UNC and its collaborative partners
This position requires periodic domestic and international travel to support scientific conferences, research collaborations, and program activities.
The Research Scientist will join the Metabolomics and Proteomics (MAP) Core at the University of North Carolina at Chapel Hill, a collaborative shared research facility that supports investigators across UNC and external partners through advanced mass spectrometry, and data analysis services. This position offers an exciting opportunity to contribute to cutting-edge translational and biomedical research while working with multidisciplinary teams on a wide range of sponsored research projects.
The Research Scientist will provide scientific expertise in drug discovery, mass spectrometry, and analytical method development. Responsibilities include preparing and processing samples for small-molecule analyses; operating, maintaining, and troubleshooting advanced instrumentation, including automated liquid handlers, liquid chromatography (LC) and mass spectrometry (MS) platforms; analyzing and interpreting targeted and untargeted experimental data; maintenance and communication of research records and project achievements.
Working with a high degree of independence, the Research Scientist will serve as a key scientific resource supporting team members and collaborators to design experiments, troubleshoot technical challenges, interpret results, and support successful project completion. The position may also provide technical training and guidance on laboratory procedures, instrumentation operation, and best practices to team members and research personnel, advancing the research mission of SGC-UNC and its collaborative partners
This position requires periodic domestic and international travel to support scientific conferences, research collaborations, and program activities.